NFkB
February 01, 2005
| Created
January 21, 2005
| Proteoetymology
NFkappaB: KBF2_HUMAN
nuclear factor that binds the kappa immunoglobulin light chain gene enhancer in B cells. (So kappa doesnt mean it is the eighth in a series, for Ig light chains are called kappa and lambda). First known use of NFkappaB is from David Baltimore's lab in 1987
The B in B cells, as any fule kno, is from Bursa of Fabricius, the lymphoid organ from they originate in Birds. Earliest usage of this I can find is 1972 (JSTOR access required) though they say the usage by then was common. At the time it wasn't known where B cells matured, unlike T cells.
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